Negative regulation of defense response to bacterium

Across TCGA cell cohorts, RNA activity of the Negative regulation of defense response to bacterium pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KATNB1, PARK7, and SCTR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KATNB1 grouped by Negative regulation of defense response to bacterium-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KATNB1 →	-0.262	-0.910	.004	<.001	2	4
LUNG_NSCLC_LUAD	PARK7 →	-0.186	-0.660	.006	.004	3	3
LUNG_NSCLC_LUAD	SCTR →	-0.153	-0.972	<.001	<.001	3	3
BREAST	PRPF4B →	-0.216	-0.623	<.001	.004	3	3
BREAST	STAT5A →	+0.080	+0.736	<.001	<.001	3	3
BREAST	BRD4 →	-0.228	-0.754	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KATNB1 by Negative regulation of defense response to bacterium activity — BREAST

Explore this box plot interactively →