Regulation of cellular response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3P43, RAB30, and TNS4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to oxidative stress activity versus H3P43 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	H3P43 →	+0.762	+0.158	.005	.004	3	4
COAD	RAB30 →	+0.303	+0.126	.008	.008	3	3
HNSC	TNS4 →	-0.588	-0.224	.009	.001	3	3
HNSC	NXPE3 →	+0.436	+0.185	.001	.007	3	3
CCRCC	TTC3 →	-0.289	-0.167	<.001	.005	3	3
CCRCC	DDX11L10 →	+0.068	+0.162	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900407 vs H3P43 — GBM

Explore this scatter interactively →