Regulation of cellular response to oxidative stress

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cellular response to oxidative stress pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and KIRP, show the opposite pattern, with lower activity in tumor tissue.

COAD, KICH, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	II,III,IV	+0.049	<.001	10	view →
KICH	Male	II,III,IV	−0.074	<.001	8	view →
LUSC	Male	II,III,IV	+0.037	<.001	8	view →
KIRP	Male	All	−0.046	<.001	6	view →
BRCA	Female	II,III,IV	−0.033	<.001	6	view →
LIHC	All	II,III,IV	−0.031	<.001	6	view →
LUAD	Male	All	+0.037	<.001	5	view →
STAD	Male	II,III,IV	+0.043	.002	4	view →
THCA	Female	All	−0.029	<.001	4	view →
KIRC	Female	III,IV	−0.025	.006	3	view →
HNSC	All	All	+0.020	.017	3	view →
UCEC	All	IV	+0.074	.021	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:1900407–COAD

Open the COAD breakdown →