Q-omics provides the consensus-scored H3P43 profile across patient tissues and cancer cell-line models. H3P43 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, H3P43 is differentially expressed in 9, with the highest sampling consensus in BRCA. Additionally, H3P43 RNA expression shows 13,177 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight HNSC, BRCA, and GBM as cancer lineages where H3P43 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for H3P43 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes H3P43 survival associations across molecular data types. H3P43 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible H3P43 RNA expression–survival associations across cancer types. High H3P43 expression shows unfavorable associations in ACC, LIHC and ESCA, but favorable associations in HNSC, SKCM and UCS. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .004). Together, the overview and detailed table identify HNSC as the clearest survival context for H3P43 RNA expression.
This table summarizes H3P43 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for H3P43. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. H3P43 shows higher tumor expression in BRCA, COAD, LUSC, UCEC, BLCA and CHOL. The BRCA box plot shows higher H3P43 RNA expression in tumor versus normal tissue (log2 FC = +0.269, t-test p < 0.001).
This table shows molecular features associated with H3P43 in patient tissues and cancer cell lines. In patient samples, H3P43 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
