Positive regulation of long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN4, RIMS3, and RN7SL646P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of long-term synaptic potentiation activity versus CLCN4 in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLCN4 →	+0.519	+0.720	.006	.002	3	4
LUAD	RIMS3 →	+0.520	+0.829	.008	<.001	3	4
UCEC	RN7SL646P →	+0.560	+0.461	.002	.005	3	4
LSCC	ARMH1 →	+0.255	+0.498	.009	.008	3	3
LSCC	MTND3P5 →	+0.096	+0.553	.009	.006	3	3
BRCA	PPFIA2-AS1 →	+0.126	+0.375	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900273 vs CLCN4 — HNSC

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