Positive regulation of long-term synaptic potentiation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of long-term synaptic potentiation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 22 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Positive regulation of long-term synaptic potentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and LUAD, show the opposite pattern, with higher activity associated with better survival.

CESC, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.705	0.855	.006	84	view →
MESO	OS	Tertile	All	0.221	0.467	<.001	60	view →
ACC	OS	Tertile	All	0.981	0.797	.002	56	view →
BRCA	DFS	Median	II,III,IV	0.858	0.916	.003	40	view →
LUSC	OS	Quartile	II,III,IV	0.613	0.826	<.001	31	view →
COAD	DFS	Median	III,IV	0.587	0.736	.009	27	view →
LUAD	OS	Median	III,IV	0.470	0.195	.002	21	view →
THYM	DFS	Median	II,III,IV	1.000	0.509	.001	19	view →
UVM	OS	Tertile	All	0.823	0.555	.019	17	view →
BLCA	DFS	Quartile	III,IV	0.311	0.629	.001	16	view →
SKCM	DFS	Tertile	II,III,IV	0.174	0.309	.017	14	view →
UCS	OS	Tertile	IV	0.336	0.686	.047	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:1900273–CESC (OS)

Open the CESC breakdown →