Positive regulation of cellular response to insulin stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular response to insulin stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, IRS1, and IRS1_S330, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular response to insulin stimulus activity versus SMC2 in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC2 →	-0.497	-0.048	<.001	<.001	3	7
BRCA	IRS1 →	+0.387	+0.046	<.001	<.001	3	7
LSCC	IRS1_S330 →	+0.733	+0.047	.001	<.001	3	7
UCEC	VCL →	+0.627	+0.053	<.001	.002	3	7
BRCA	RSF1_S397 →	-0.730	-0.049	<.001	<.001	3	6
BRCA	SMC4 →	-0.453	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900078 vs SMC2 — BRCA

Explore this scatter interactively →