Positive regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTCD3, COQ8A, and BPNT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular response to insulin stimulus activity versus PTCD3 in LUNG_NSCLC_LUSC (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PTCD3 →	-0.794	-0.321	.006	<.001	3	5
SOFT_TISSUE	COQ8A →	-0.732	-0.282	<.001	.002	3	5
CNS	BPNT1 →	-0.381	-0.240	.004	.002	3	5
PANCREAS	FAM117B →	-0.994	-0.248	.002	.004	3	4
LIVER	TTC38 →	-1.337	-0.375	.004	.009	3	4
SOFT_TISSUE	SETDB1 →	-0.698	-0.295	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900078 vs PTCD3 — LUNG_NSCLC_LUSC

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