Amyloid-beta clearance by transcytosis

Across TCGA patient cohorts, RNA activity of the Amyloid-beta clearance by transcytosis pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAN2B2, KIAA1109, and SEC24D, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta clearance by transcytosis activity versus MAN2B2 in SCLC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	MAN2B2 →	+1.165	+0.162	<.001	<.001	3	32
KICH	KIAA1109 →	+1.262	+0.035	<.001	.005	2	33
THYM	SEC24D →	+1.303	+0.126	<.001	<.001	3	32
KIRC	GSN-AS1 →	+0.479	+0.059	<.001	<.001	3	32
UCS	SH3BP5 →	+1.842	+0.093	<.001	<.001	3	31
THYM	ARHGAP29 →	+2.094	+0.135	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150093 vs MAN2B2 — SCLC

Explore this scatter interactively →