Disruption of cellular anatomical structure in another organism

Across TCGA cell cohorts, RNA activity of the Disruption of cellular anatomical structure in another organism pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPTOR, RPL36AL, and KCTD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEPTOR grouped by Disruption of cellular anatomical structure in another organism-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DEPTOR →	-1.092	-0.693	.006	.004	3	3
KIDNEY	RPL36AL →	-0.665	-1.212	.007	.009	3	3
BLOOD_Leukemia	KCTD2 →	+0.744	+0.853	.006	.009	3	3
STOMACH	OAZ3 →	-0.436	-1.016	.004	.002	3	2
STOMACH	COG7 →	-0.734	-1.128	<.001	.008	2	3
OVARY	USP31 →	-0.494	-0.686	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEPTOR by Disruption of cellular anatomical structure in another organism activity — OVARY

Explore this box plot interactively →