Disruption of cellular anatomical structure in another organism

Across TCGA pan-cancer cohorts, RNA activity of the Disruption of cellular anatomical structure in another organism pathway differs between tumor and matched normal tissue in 8 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUAD and KICH, show the opposite pattern, with lower activity in tumor tissue.

KIRC, COAD, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.783	<.001	9	view →
COAD	All	II,III,IV	+0.452	<.001	7	view →
LUAD	All	All	−0.681	<.001	6	view →
THCA	Female	All	+0.345	.005	3	view →
KICH	Female	All	−0.942	.007	2	view →
LUSC	Male	All	−0.779	<.001	2	view →
READ	All	All	+0.602	.031	2	view →
PAAD	Male	All	−0.530	.018	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 8 strongest of 8 lineages.

GO:0140975–KIRC

Open the KIRC breakdown →