Cellular detoxification of aldehyde

Across TCGA patient cohorts, RNA activity of the Cellular detoxification of aldehyde pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1A1, ALDH1A1_S413, and ME1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular detoxification of aldehyde activity versus ALDH1A1 in OV (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ALDH1A1 →	+0.688	+0.062	<.001	<.001	3	9
UCEC	ALDH1A1_S413 →	+0.969	+0.117	<.001	.001	3	7
GBM	ME1 →	+0.474	+0.057	<.001	<.001	3	7
CCRCC	CDC42BPB →	+0.190	+0.046	<.001	<.001	3	6
GBM	SEPTIN4_S117 →	+0.988	+0.088	.002	<.001	3	6
PDAC	SPTAN1_S1217 →	+0.366	+0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110095 vs ALDH1A1 — OV

Explore this scatter interactively →