Cellular detoxification of aldehyde

Across TCGA pan-cancer cohorts, RNA activity of the Cellular detoxification of aldehyde pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Cellular detoxification of aldehyde pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

BRCA, SKCM, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.952	0.895	<.001	100	view →
SKCM	OS	Quartile	II,III,IV	0.549	0.278	.008	28	view →
KICH	DFS	Median	II,III,IV	1.000	0.613	.011	25	view →
SARC	OS	Tertile	All	0.938	0.758	<.001	22	view →
LUSC	OS	Quartile	II,III,IV	0.950	0.581	.008	22	view →
MESO	OS	Tertile	II,III,IV	0.787	0.278	.012	18	view →
OV	DFS	Tertile	All	0.425	0.342	.032	12	view →
ACC	OS	Median	IV	0.778	0.307	.019	11	view →
KIRP	OS	Tertile	All	0.910	0.982	.007	11	view →
HNSC	DFS	Quartile	All	0.358	0.634	.008	9	view →
DLBC	OS	Tertile	All	1.000	0.768	.035	8	view →
UVM	DFS	Tertile	III,IV	0.296	0.791	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0110095–BRCA (OS)

Open the BRCA breakdown →