Cellular detoxification of aldehyde

Across TCGA cell cohorts, RNA activity of the Cellular detoxification of aldehyde pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A2, DYSF, and ALDH1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular detoxification of aldehyde activity versus SLC37A2 in LARGE_INTESTINE (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC37A2 →	-1.112	-0.252	.005	<.001	3	6
STOMACH	DYSF →	-2.167	-0.442	.007	.001	3	6
LUNG_NSCLC_LUAD	ALDH1A1 →	+4.198	+0.302	<.001	<.001	3	6
LIVER	ELFN2 →	-3.281	-0.575	<.001	.001	3	5
STOMACH	ACAD10 →	+0.911	+0.459	.006	.001	3	5
STOMACH	ARHGAP29 →	-3.100	-0.390	.004	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110095 vs SLC37A2 — LARGE_INTESTINE

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