Response to interleukin-7

Across TCGA cell cohorts, RNA activity of the Response to interleukin-7 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT3, SOCS3, and BHLHE40, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-7 activity versus STAT3 in BLOOD_Lymphoma (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STAT3 →	+2.797	+1.916	<.001	<.001	3	3
BLOOD_Lymphoma	SOCS3 →	+4.249	+1.916	.001	<.001	3	3
BLOOD_Lymphoma	BHLHE40 →	+5.655	+2.010	.001	<.001	3	3
BLOOD_Lymphoma	IRF9 →	+2.323	+2.251	<.001	<.001	3	3
BLOOD_Lymphoma	CTTN →	+3.265	+1.581	<.001	<.001	3	2
BLOOD_Lymphoma	PIGS →	+1.110	+1.924	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098760 vs STAT3 — BLOOD_Lymphoma

Explore this scatter interactively →