Response to interleukin-7

Across TCGA pan-cancer cohorts, RNA activity of the Response to interleukin-7 pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Response to interleukin-7 pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

HNSC, UCS, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.418	0.204	<.001	93	view →
UCS	DFS	Median	IV	0.981	0.450	.004	60	view →
KIRP	OS	Tertile	All	0.580	0.925	<.001	58	view →
KIRC	OS	Median	All	0.550	0.698	<.001	56	view →
LUAD	DFS	Tertile	All	0.818	0.627	.002	29	view →
COAD	DFS	Quartile	II,III,IV	0.626	0.861	<.001	27	view →
SCLC	DFS	Quartile	III,IV	0.854	0.297	.006	26	view →
ACC	DFS	Quartile	All	0.426	0.850	<.001	26	view →
LAML	DFS	Tertile	All	0.251	0.598	.010	24	view →
LIHC	OS	Median	III,IV	0.411	0.748	<.001	23	view →
LUSC	DFS	Quartile	II,III,IV	0.284	0.477	.009	21	view →
READ	OS	Tertile	III,IV	0.842	0.235	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0098760–HNSC (DFS)

Open the HNSC breakdown →