Calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFX, MOAP1, and TM6SF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion import across plasma membrane activity versus ZFX in SKIN (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZFX →	+0.369	+0.882	.008	.005	3	4
LUNG_SCLC	MOAP1 →	+0.974	+0.839	<.001	.005	3	4
LUNG_NSCLC_LUSC	TM6SF1 →	+1.573	+1.790	.006	<.001	2	4
LUNG_NSCLC_LUSC	CMTR1 →	+0.875	+1.790	<.001	<.001	2	4
BLOOD_Leukemia	FUNDC2 →	+0.675	+1.310	<.001	<.001	3	3
BLOOD_Leukemia	ADGRF3 →	+0.818	+0.951	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098703 vs ZFX — SKIN

Explore this scatter interactively →