Calcium ion import across plasma membrane

Across TCGA pan-cancer cohorts, RNA activity of the Calcium ion import across plasma membrane pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 52 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Calcium ion import across plasma membrane pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and KIRP, show the opposite pattern, with higher activity associated with better survival.

SKCM, LGG, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.630	0.802	.001	54	view →
LGG	OS	Median	All	0.521	0.339	<.001	41	view →
KIRP	DFS	Median	All	0.788	0.523	.001	36	view →
KIRC	DFS	Tertile	All	0.882	0.711	<.001	36	view →
MESO	OS	Median	All	0.310	0.453	.036	17	view →
ACC	OS	Quartile	All	0.759	0.296	.006	14	view →
UCS	DFS	Tertile	All	0.527	0.129	.032	12	view →
READ	OS	Quartile	II,III,IV	0.663	0.967	.028	9	view →
CESC	DFS	Tertile	All	0.840	0.694	.015	8	view →
SCLC	DFS	Quartile	II,III,IV	0.167	0.558	.015	8	view →
LUAD	DFS	Median	All	0.485	0.261	.007	7	view →
STAD	DFS	Tertile	II,III,IV	0.661	0.394	.010	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0098703–SKCM (DFS)

Open the SKCM breakdown →