De novo centriole assembly

Across TCGA patient cohorts, RNA activity of the De novo centriole assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1_S782, MCM2_S139, and MCM7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, De novo centriole assembly activity versus RIF1_S782 in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RIF1_S782 →	+0.780	+0.160	<.001	<.001	3	8
GBM	MCM2_S139 →	+0.937	+0.141	<.001	<.001	3	8
LSCC	MCM7 →	+0.548	+0.071	<.001	<.001	3	8
OV	UNG_T60 →	+0.510	+0.049	.003	.002	3	8
LUAD	TOP2A_S1247 →	+1.141	+0.090	<.001	<.001	3	8
LUAD	RFC1_T506 →	+1.164	+0.109	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097742 vs RIF1_S782 — GBM

Explore this scatter interactively →