Hypoxia-inducible factor-1alpha signaling pathway

Across TCGA cell cohorts, RNA activity of the Hypoxia-inducible factor-1alpha signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENTPD7, TSPAN1, and ANKRD6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENTPD7 grouped by Hypoxia-inducible factor-1alpha signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ENTPD7 →	-0.938	-1.302	.008	.008	2	6
LUNG_SCLC	TSPAN1 →	-2.261	-1.190	<.001	.009	3	4
LUNG_NSCLC_LUSC	ANKRD6 →	-1.771	-1.260	.001	.007	3	4
BLOOD_Leukemia	BCAS4 →	+1.780	+1.019	.008	.004	3	4
UPPER_AERODIGESTIVE_TRACT	MNX1 →	-0.792	-1.154	.009	.004	3	4
LARGE_INTESTINE	ARG1 →	-0.137	-0.923	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENTPD7 by Hypoxia-inducible factor-1alpha signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →