Hypoxia-inducible factor-1alpha signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Hypoxia-inducible factor-1alpha signaling pathway pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Hypoxia-inducible factor-1alpha signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LAML and PRAD, show the opposite pattern, with higher activity associated with better survival.

CESC, KIRP, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.473	0.675	<.001	92	view →
KIRP	DFS	Median	All	0.860	0.956	<.001	81	view →
KICH	OS	Median	All	0.678	0.977	<.001	73	view →
UCS	OS	Tertile	All	0.567	0.831	.011	42	view →
KIRC	DFS	Quartile	II,III,IV	0.381	0.662	.003	37	view →
LGG	OS	Median	All	0.744	0.909	<.001	35	view →
LIHC	OS	Median	All	0.604	0.744	.002	21	view →
UCEC	DFS	Tertile	All	0.767	0.899	<.001	20	view →
LAML	DFS	Median	All	0.547	0.218	.005	18	view →
PRAD	DFS	Median	All	0.923	0.847	.004	18	view →
CHOL	DFS	Median	All	0.630	0.191	.012	17	view →
THCA	DFS	Quartile	IV	1.000	0.572	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0097411–CESC (OS)

Open the CESC breakdown →