Immunological memory process

Across TCGA patient cohorts, RNA activity of the Immunological memory process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIFK, PPM1F, and RRP36_S73, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunological memory process activity versus NIFK in LSCC (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NIFK →	-0.395	-0.049	<.001	<.001	3	8
CCRCC	PPM1F →	+0.270	+0.071	<.001	<.001	3	8
LUAD	RRP36_S73 →	-0.762	-0.066	<.001	<.001	3	7
BRCA	SRPK1_S311 →	-0.697	-0.043	<.001	<.001	3	7
BRCA	TNS1 →	+0.339	+0.037	<.001	<.001	3	7
BRCA	UBE2O_S896 →	-0.750	-0.028	.003	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090713 vs NIFK — LSCC

Explore this scatter interactively →