Immunological memory process

Across TCGA pan-cancer cohorts, RNA activity of the Immunological memory process pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Immunological memory process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

BLCA, SKCM, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.773	0.454	<.001	58	view →
SKCM	OS	Tertile	All	0.439	0.268	<.001	55	view →
KIRP	OS	Tertile	All	0.939	0.803	.001	49	view →
LGG	OS	Median	All	0.742	0.861	<.001	48	view →
LAML	DFS	Quartile	All	0.188	0.589	<.001	34	view →
GBM	DFS	Median	All	0.177	0.383	.001	32	view →
CHOL	DFS	Median	All	0.718	0.109	<.001	26	view →
HNSC	DFS	Median	All	0.761	0.663	.007	22	view →
SARC	DFS	Median	All	0.722	0.541	.005	17	view →
THCA	OS	Tertile	All	0.942	1.000	.004	16	view →
ACC	OS	Median	IV	0.791	0.319	.003	12	view →
KIRC	DFS	Median	IV	0.564	0.341	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0090713–BLCA (OS)

Open the BLCA breakdown →