Cellular response to oxygen-glucose deprivation

Across TCGA patient cohorts, RNA activity of the Cellular response to oxygen-glucose deprivation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAF1, DTHD1, and LINC02736, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen-glucose deprivation activity versus PAF1 in BRCA (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAF1 →	-0.483	-0.514	.004	.005	3	3
GBM	DTHD1 →	+0.738	+0.424	.003	.003	3	3
LSCC	LINC02736 →	-0.225	-0.419	.002	.007	3	3
GBM	NR2C2AP →	-0.228	-0.411	.005	.004	3	3
LUAD	MIR3143 →	-0.815	-0.610	.003	<.001	3	3
CCRCC	MIR455 →	+0.683	+0.524	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090650 vs PAF1 — BRCA

Explore this scatter interactively →