Cellular response to oxygen-glucose deprivation

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to oxygen-glucose deprivation pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Cellular response to oxygen-glucose deprivation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LGG, show the opposite pattern, with higher activity associated with better survival.

KIRP, LGG, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	III,IV	1.000	0.222	.004	43	view →
LGG	DFS	Quartile	All	0.598	0.291	<.001	36	view →
COAD	OS	Tertile	III,IV	0.640	0.947	<.001	33	view →
LIHC	DFS	Median	All	0.461	0.603	.001	23	view →
CESC	OS	Median	All	0.838	0.902	.018	20	view →
KIRC	DFS	Tertile	IV	0.198	0.426	.013	20	view →
SKCM	OS	Quartile	All	0.301	0.487	.006	18	view →
MESO	OS	Tertile	All	0.240	0.805	.001	18	view →
ACC	DFS	Median	IV	0.472	0.089	.012	17	view →
THYM	OS	Median	II,III,IV	1.000	0.670	.001	16	view →
OV	DFS	Median	IV	0.343	0.555	.019	12	view →
GBM	DFS	Quartile	All	0.546	0.241	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0090650–KIRP (DFS)

Open the KIRP breakdown →