Protein localization to nuclear envelope

Across TCGA patient cohorts, RNA activity of the Protein localization to nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP155, USP14, and UBFD1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to nuclear envelope activity versus NUP155 in DLBC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	NUP155 →	+1.081	+0.060	<.001	<.001	3	34
DLBC	USP14 →	+0.968	+0.074	<.001	<.001	3	33
KICH	UBFD1 →	+0.792	+0.074	<.001	<.001	3	33
DLBC	NUP107 →	+1.064	+0.080	<.001	.003	3	33
ACC	TIMELESS →	+1.357	+0.056	<.001	<.001	3	33
LIHC	SMC4 →	+1.720	+0.084	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090435 vs NUP155 — DLBC

Explore this scatter interactively →