Positive regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC3, RFC4, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle spindle assembly checkpoint activity versus RFC3 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC3 →	+0.463	+0.135	<.001	<.001	3	10
GBM	RFC4 →	+0.479	+0.159	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.397	+0.146	<.001	<.001	3	10
LUAD	RRM2 →	+1.019	+0.163	<.001	<.001	3	10
GBM	SMC2 →	+0.774	+0.139	<.001	<.001	3	10
GBM	SMC4 →	+0.733	+0.136	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090267 vs RFC3 — GBM

Explore this scatter interactively →