Positive regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of mitotic cell cycle spindle assembly checkpoint pathway differs between tumor and matched normal tissue in 17 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

HNSC, KIRC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Male	IV	+0.117	<.001	12	view →
KIRC	Male	IV	+0.101	<.001	12	view →
KIRP	All	IV	+0.187	<.001	11	view →
BLCA	Male	III,IV	+0.164	<.001	11	view →
LUAD	Male	III,IV	+0.173	<.001	9	view →
STAD	All	III,IV	+0.163	<.001	9	view →
LIHC	Female	II,III,IV	+0.139	<.001	9	view →
LUSC	Female	II,III,IV	+0.231	<.001	8	view →
UCEC	All	II,III,IV	+0.208	<.001	8	view →
COAD	Male	All	+0.057	<.001	8	view →
THCA	All	III,IV	+0.041	.004	7	view →
BRCA	All	II,III,IV	+0.111	<.001	6	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 17 lineages.

GO:0090267–HNSC

Open the HNSC breakdown →