Regulation of spindle organization

Across TCGA patient cohorts, RNA activity of the Regulation of spindle organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, SETDB1_S1066, and SMC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spindle organization activity versus RPL12_S38 in LUAD (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.320	+0.072	<.001	<.001	3	10
GBM	SETDB1_S1066 →	+1.283	+0.088	<.001	<.001	3	10
UCEC	SMC2 →	+0.696	+0.109	<.001	<.001	3	10
LUAD	SMC4 →	+0.679	+0.084	<.001	<.001	3	10
LUAD	BAZ1B_S349 →	+1.053	+0.066	<.001	<.001	3	10
LUAD	TOP2A →	+1.136	+0.082	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090224 vs RPL12_S38 — LUAD

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