GO:0090156Ontology (GO BP)GO biological process · ~5 member genes
Q-omics provides the Intracellular sphingolipid homeostasis (GO:0090156) pathway profile, scoring each patient from the combined activity of its roughly 5 member genes. Pathway activity is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 11, with the highest sampling consensus in STAD. Additionally, pathway RNA activity shows 35,831 significant cross-omics associations, again with the highest sampling consensus in STAD. Together, these results highlight KIRC, and STAD as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Intracellular sphingolipid homeostasis survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Intracellular sphingolipid homeostasis activity shows favorable associations in SKCM and LUAD, but unfavorable associations in KIRC, UVM, UCEC and LGG. In the KIRC Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p < 0.001). KIRC ranks highest by sampling consensus for Intracellular sphingolipid homeostasis.
This table summarizes Intracellular sphingolipid homeostasis tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 11 cancer types, while mass-spec protein activity shows differences in 2. The strongest signals are in STAD for RNA and COAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across STAD, BLCA, LIHC and COAD and lower tumor activity in KICH and BRCA. In the STAD box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.071, t-test p < 0.001).
This table shows molecular features associated with Intracellular sphingolipid homeostasis pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in STAD. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in OVARY.
