Intracellular sphingolipid homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular sphingolipid homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTN4, PLD2, and CENPL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTN4 grouped by Intracellular sphingolipid homeostasis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RTN4 →	-0.298	-1.193	.008	.003	3	4
SOFT_TISSUE	PLD2 →	+0.252	+0.399	<.001	.001	3	4
LUNG_NSCLC_LUAD	CENPL →	-0.180	-0.931	.003	.005	3	3
SOFT_TISSUE	SLC29A2 →	+0.268	+0.412	.005	.008	3	3
KIDNEY	ZC3H14 →	+0.335	+0.467	.006	.002	3	3
SKIN	TSPAN12 →	+0.348	+1.407	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTN4 by Intracellular sphingolipid homeostasis activity — LUNG_SCLC

Explore this box plot interactively →