Intracellular sphingolipid homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular sphingolipid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL10P12, LRRC39, and SGCD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sphingolipid homeostasis activity versus RPL10P12 in BRCA (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL10P12 →	-1.435	-0.256	<.001	<.001	3	4
HNSC	LRRC39 →	+0.945	+0.558	.001	<.001	3	4
HNSC	SGCD →	+0.804	+0.453	.002	<.001	3	4
GBM	MTURN →	+1.230	+0.734	<.001	<.001	3	4
BRCA	PAM16 →	-0.460	-0.160	.003	.002	3	3
BRCA	RPL3P7 →	-1.102	-0.168	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090156 vs RPL10P12 — BRCA

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