Intracellular sphingolipid homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular sphingolipid homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATPAF1, SRCIN1_S343, and LRSAM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sphingolipid homeostasis activity versus ATPAF1 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATPAF1 →	+0.313	+0.087	.002	<.001	3	5
GBM	SRCIN1_S343 →	+0.979	+0.090	<.001	<.001	3	5
GBM	LRSAM1 →	+0.290	+0.081	<.001	<.001	3	4
BRCA	GOLGA1 →	+0.321	+0.059	<.001	<.001	3	4
GBM	ACOT7 →	+0.308	+0.064	.006	<.001	3	4
GBM	CEP170B →	+0.338	+0.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090156 vs ATPAF1 — GBM

Explore this scatter interactively →