Negative regulation of sphingolipid biosynthetic process
associated omics data
GO:0090155Ontology (GO BP)GO biological process · ~6 member genes
Q-omics provides the Negative regulation of sphingolipid biosynthetic process (GO:0090155) pathway profile, scoring each patient from the combined activity of its roughly 6 member genes. Pathway activity is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 14, with the highest sampling consensus in THCA. Additionally, pathway RNA activity shows 35,404 significant cross-omics associations, again with the highest sampling consensus in HNSC. Together, these results highlight UCEC, THCA, and HNSC as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Negative regulation of sphingolipid biosynthetic process survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Negative regulation of sphingolipid biosynthetic process activity shows unfavorable associations in UCEC, UVM, KIRC, LGG, COAD and MESO. In the UCEC Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p < 0.001). UCEC ranks highest by sampling consensus for Negative regulation of sphingolipid biosynthetic process.
This table summarizes Negative regulation of sphingolipid biosynthetic process tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 14 cancer types, while mass-spec protein activity shows differences in 1. The strongest signals are in THCA for RNA and PDAC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across THCA, LUAD, COAD, STAD and LUSC and lower tumor activity in KIRC. In the THCA box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.084, t-test p < 0.001).
This table shows molecular features associated with Negative regulation of sphingolipid biosynthetic process pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in HNSC. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in BREAST.
