Negative regulation of sphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of sphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHNYN, KIRREL2, and JUND, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KHNYN grouped by Negative regulation of sphingolipid biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KHNYN →	-0.683	-1.755	.001	.001	3	4
SKIN	KIRREL2 →	+0.635	+0.767	.001	.004	3	3
LIVER	JUND →	-1.916	-1.755	.004	.001	3	3
LIVER	SLFN13 →	+3.729	+1.755	.001	.001	3	3
BLOOD_Lymphoma	CAMKV →	+1.573	+2.111	.001	.001	3	3
STOMACH	SRP9 →	+0.513	+1.081	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KHNYN by Negative regulation of sphingolipid biosynthetic process activity — LIVER

Explore this box plot interactively →