Negative regulation of sphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of sphingolipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETD2_S614, SRPK1_S51, and TNS2_T91, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sphingolipid biosynthetic process activity versus SETD2_S614 in COAD (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SETD2_S614 →	+1.015	+1.014	<.001	<.001	3	4
OV	SRPK1_S51 →	-1.068	-0.704	<.001	<.001	3	4
COAD	TNS2_T91 →	+0.864	+0.722	.001	.005	3	3
OV	AAGAB_S311 →	-1.239	-2.050	.001	<.001	3	3
OV	PRKAA1_S486 →	+0.836	+0.701	<.001	<.001	3	3
COAD	TLK2_S111 →	-0.567	-1.910	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090155 vs SETD2_S614 — COAD

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