Negative regulation of sphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of sphingolipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAU, C1QC, and CRTAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sphingolipid biosynthetic process activity versus PLAU in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLAU →	+0.583	+0.053	<.001	<.001	3	6
CCRCC	C1QC →	+0.646	+0.053	.001	<.001	2	6
BRCA	CRTAP →	+0.543	+0.051	<.001	<.001	3	5
BRCA	P3H1 →	+0.495	+0.049	<.001	<.001	3	5
LUAD	PLOD1 →	+0.449	+0.060	<.001	<.001	3	5
LUAD	SPP1_S195 →	+0.766	+0.039	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090155 vs PLAU — LUAD

Explore this scatter interactively →