Bundle of His cell to Purkinje myocyte signaling

Across TCGA patient cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL1A2, THBS2, and PPFIBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bundle of His cell to Purkinje myocyte signaling activity versus COL1A2 in LUAD (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COL1A2 →	+0.890	+0.149	<.001	<.001	3	7
LUAD	THBS2 →	+1.140	+0.117	<.001	<.001	3	7
BRCA	PPFIBP1 →	+0.334	+0.061	.001	<.001	3	7
GBM	CACNA2D1 →	+0.726	+0.437	<.001	.002	3	6
GBM	COL1A1 →	+0.791	+0.294	.003	.004	3	6
GBM	COL6A2 →	+0.787	+0.348	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086028 vs COL1A2 — LUAD

Explore this scatter interactively →