Bundle of His cell to Purkinje myocyte signaling

Across TCGA pan-cancer cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte signaling pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Bundle of His cell to Purkinje myocyte signaling pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and BRCA, show the opposite pattern, with higher activity associated with better survival.

READ, DLBC, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	All	0.240	0.721	<.001	80	view →
DLBC	OS	Tertile	All	0.363	1.000	.001	40	view →
ESCA	DFS	Median	III,IV	0.585	0.288	<.001	29	view →
BRCA	DFS	Tertile	II,III,IV	0.924	0.853	.002	23	view →
THYM	DFS	Tertile	All	0.532	0.954	.002	20	view →
HNSC	OS	Tertile	III,IV	0.773	0.651	.020	14	view →
UCEC	OS	Median	All	0.953	0.898	.030	12	view →
CESC	OS	Median	All	0.808	0.926	<.001	10	view →
CHOL	OS	Median	IV	0.136	0.829	.008	9	view →
PAAD	OS	Median	All	0.712	0.503	.011	8	view →
LUAD	DFS	Quartile	III,IV	0.565	0.770	.026	8	view →
OV	OS	Median	IV	0.270	0.464	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0086028–READ (OS)

Open the READ breakdown →