Response to cell cycle checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Response to cell cycle checkpoint signaling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, TOP2A, and SPC24, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cell cycle checkpoint signaling activity versus SMC4 in GBM (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.574	+0.040	<.001	<.001	3	7
HNSC	TOP2A →	+0.840	+0.058	<.001	<.001	3	7
GBM	SPC24 →	+0.702	+0.038	<.001	<.001	3	7
LSCC	CHTF18 →	+0.570	+0.059	<.001	<.001	3	7
GBM	NCAPG →	+0.481	+0.042	<.001	<.001	3	7
LSCC	ORC6_T195 →	+1.001	+0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072396 vs SMC4 — GBM

Explore this scatter interactively →