Response to cell cycle checkpoint signaling

Across TCGA pan-cancer cohorts, RNA activity of the Response to cell cycle checkpoint signaling pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Response to cell cycle checkpoint signaling pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and READ, show the opposite pattern, with higher activity associated with better survival.

KIRC, MESO, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.561	0.684	<.001	122	view →
MESO	OS	Median	II,III,IV	0.251	0.531	<.001	111	view →
KIRP	OS	Quartile	All	0.611	0.883	<.001	68	view →
UCS	DFS	Tertile	II,III,IV	0.645	0.219	.002	52	view →
LIHC	DFS	Tertile	All	0.431	0.622	<.001	41	view →
LUSC	OS	Tertile	III,IV	0.336	0.870	.004	31	view →
LGG	OS	Tertile	All	0.716	0.873	<.001	30	view →
LAML	DFS	Median	All	0.379	0.738	<.001	24	view →
CHOL	DFS	Tertile	II,III,IV	0.105	0.603	.010	23	view →
SCLC	OS	Tertile	II,III,IV	0.370	0.771	.007	23	view →
STAD	DFS	Quartile	II,III,IV	0.264	0.547	.004	15	view →
SARC	OS	Tertile	All	0.428	0.743	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0072396–KIRC (OS)

Open the KIRC breakdown →