Cellular response to epinephrine stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to epinephrine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF15, CENPA, and TRAIP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to epinephrine stimulus activity versus KIF15 in UCEC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF15 →	-0.836	-0.155	.001	.002	3	7
CCRCC	CENPA →	-0.591	-0.118	<.001	.001	2	7
GBM	TRAIP →	-0.523	-0.194	.008	.002	3	6
GBM	KIF20A →	-0.715	-0.174	.001	.001	3	6
LUAD	TOP2A →	-0.968	-0.272	<.001	.004	3	5
LUAD	HROB →	-1.074	-0.464	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071872 vs KIF15 — UCEC

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