Cellular response to epinephrine stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to epinephrine stimulus pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in breast invasive carcinoma (BRCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BRCA and KIRP, show the opposite pattern, with lower activity in tumor tissue.

BRCA, COAD, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BRCA	All	III,IV	−0.069	<.001	6	view →
COAD	Female	II,III,IV	+0.064	<.001	5	view →
KIRP	All	II,III,IV	−0.043	.007	4	view →
KICH	Female	All	+0.101	<.001	3	view →
STAD	Female	All	+0.072	.025	3	view →
THCA	Female	II,III,IV	−0.036	.005	3	view →
READ	Male	All	+0.083	.046	2	view →
UCEC	All	II,III,IV	+0.048	.035	2	view →
LUSC	All	All	+0.029	.008	2	view →
LUAD	All	All	+0.019	.013	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0071872–BRCA

Open the BRCA breakdown →