Response to epinephrine

Across TCGA patient cohorts, RNA activity of the Response to epinephrine pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAL1, ADCY4, and RCC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to epinephrine activity versus TAL1 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TAL1 →	+0.842	+0.254	<.001	.004	3	4
BRCA	ADCY4 →	+0.475	+0.305	.004	.007	3	4
BRCA	RCC1 →	-0.429	-0.401	.005	.001	3	4
LUAD	SLC26A8 →	+0.505	+0.536	.001	<.001	3	3
LUAD	HROB →	-0.659	-0.604	.005	<.001	3	3
LUAD	USP54 →	+0.398	+0.316	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071871 vs TAL1 — GBM

Explore this scatter interactively →