Response to epinephrine

Across TCGA pan-cancer cohorts, RNA activity of the Response to epinephrine pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Response to epinephrine pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and STAD, show the opposite pattern, with higher activity associated with better survival.

KIRC, UCEC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.918	0.837	<.001	110	view →
UCEC	OS	Quartile	All	0.642	0.827	<.001	70	view →
STAD	OS	Quartile	II,III,IV	0.688	0.388	.002	62	view →
ACC	OS	Median	II,III,IV	0.906	0.623	<.001	58	view →
PAAD	DFS	Quartile	All	0.628	0.224	.001	27	view →
LUAD	DFS	Quartile	All	0.407	0.180	.001	26	view →
LIHC	DFS	Quartile	III,IV	0.462	0.116	.006	25	view →
THYM	OS	Quartile	II,III,IV	0.597	1.000	.006	21	view →
OV	OS	Tertile	III,IV	0.873	0.798	.019	20	view →
CESC	DFS	Tertile	IV	0.574	0.204	.026	18	view →
BLCA	DFS	Tertile	All	0.467	0.692	.007	14	view →
READ	OS	Median	IV	0.878	0.511	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0071871–KIRC (OS)

Open the KIRC breakdown →