Endoplasmic reticulum tubular network organization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum tubular network organization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, SYNPO2_S363, and TAGLN2_S163, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum tubular network organization activity versus SYNPO2 in COAD (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SYNPO2 →	-0.536	-0.026	<.001	<.001	3	4
PDAC	SYNPO2_S363 →	-0.695	-0.043	.007	.002	3	4
OV	TAGLN2_S163 →	-0.969	-0.038	<.001	.003	3	4
LUAD	TOP2A →	+0.625	+0.021	<.001	.007	3	4
PDAC	CD34 →	-0.423	-0.029	<.001	.005	3	4
LUAD	CHAF1B_S410 →	+0.713	+0.033	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071786 vs SYNPO2 — COAD

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