Endoplasmic reticulum tubular network organization

Across TCGA pan-cancer cohorts, RNA activity of the Endoplasmic reticulum tubular network organization pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and PRAD, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KIRP, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	All	IV	+0.048	<.001	12	view →
KIRP	Female	All	+0.104	<.001	11	view →
KIRC	Male	IV	+0.062	<.001	11	view →
KICH	All	All	+0.037	<.001	7	view →
BLCA	All	All	+0.035	.035	4	view →
UCEC	All	All	−0.034	.013	4	view →
LUAD	All	All	+0.030	.003	3	view →
PAAD	Male	All	+0.059	.026	2	view →
STAD	Male	All	+0.050	.034	2	view →
PRAD	All	All	−0.015	.045	2	view →
CHOL	Male	All	+0.048	.040	1	view →
THCA	All	All	−0.012	.023	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0071786–HNSC

Open the HNSC breakdown →