Vocalization behavior

Across TCGA patient cohorts, RNA activity of the Vocalization behavior pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_T1949, SH3PXD2A, and MAP1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vocalization behavior activity versus MAP1B_T1949 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1B_T1949 →	+0.705	+0.078	.001	.002	3	7
UCEC	SH3PXD2A →	+0.391	+0.055	.002	.002	3	6
LSCC	MAP1B →	+0.805	+0.040	<.001	<.001	3	6
LSCC	MAP1B_S1016 →	+1.038	+0.057	<.001	<.001	3	6
UCEC	MAP1B_S1154 →	+0.963	+0.067	<.001	.002	3	6
LSCC	MAP1B_S1378 →	+0.783	+0.046	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071625 vs MAP1B_T1949 — UCEC

Explore this scatter interactively →