Vocalization behavior

Across TCGA pan-cancer cohorts, RNA activity of the Vocalization behavior pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and BRCA, show the opposite pattern, with lower activity in tumor tissue.

LIHC, COAD, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.059	<.001	8	view →
COAD	Male	All	−0.060	<.001	7	view →
HNSC	All	All	+0.029	<.001	7	view →
THCA	Female	All	+0.030	<.001	6	view →
BRCA	Female	All	−0.023	<.001	6	view →
UCEC	All	All	−0.060	<.001	4	view →
KIRP	All	III,IV	+0.030	.034	4	view →
CHOL	All	II,III,IV	+0.055	.008	3	view →
KICH	All	All	+0.034	.017	3	view →
READ	All	All	−0.102	.001	2	view →
PRAD	All	All	−0.031	<.001	2	view →
LUSC	All	All	+0.023	.006	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0071625–LIHC

Open the LIHC breakdown →