Hematopoietic stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POM121L14P, FAM27C, and BDKRB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell proliferation activity versus POM121L14P in CCRCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	POM121L14P →	+0.308	+0.624	<.001	<.001	3	4
HNSC	FAM27C →	+0.173	+0.476	.004	.005	3	4
LSCC	BDKRB1 →	-0.454	-0.237	<.001	.006	3	4
LSCC	FAM83A →	-1.079	-0.273	.001	.001	3	4
CCRCC	THG1L →	+0.263	+0.506	.003	.001	3	3
UCEC	SETDB1 →	+0.432	+0.586	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071425 vs POM121L14P — CCRCC

Explore this scatter interactively →